Sodium Hydroxide → HCID 10139547, compound

Participants

Reaction Steps

The compound of Example 57 (0.19 g, 0.4 mmol) was dissolved in 5 mL of THF, and 1 mL of 2N NaOH was added dropwise at 0° C. After reaction at room temperature for 3 hours, the reactant was concentrated under reduced pressure and acidified with a 2N HCl aqueous solution, extracted with ethyl acetate, and concentrated under reduced pressure. It was then recrystallized with hexane and ethyl acetate to obtain an ivory colored compound (0.07 g, yield 28%).

Provenance & Evidence