反应详情

The compound of Example 57 (0.19 g, 0.4 mmol) was dissolved in 5 mL of THF, and 1 mL of 2N NaOH was added dropwise at 0° C. After reaction at room temperature for 3 hours, the reactant was concentrated under reduced pressure and acidified with a 2N HCl aqueous solution, extracted with ethyl acetate, and concentrated under reduced pressure. It was then recrystallized with hexane and ethyl acetate to obtain an ivory colored compound (0.07 g, yield 28%).

1. customAfter reaction at room temperature for 3 hours
2. concentrationthe reactant was concentrated under reduced pressure
3. extractionextracted with ethyl acetate
4. concentrationconcentrated under reduced pressure
5. customIt was then recrystallized with hexane and ethyl acetate