Hydrochloric Acid → HCID 17924715, compound

HRID 1354171Notes

Reaction equation

HRID 1354171 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)=[N:7][N:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:9]=12)=[O:4].[OH-].[Na+].Cl>C(O)C>[F:24][C:20]1[CH:19]=[C:18]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:9]3[CH:10]=[CH:11][C:12]([C:14]([F:16])([F:15])[F:17])=[CH:13][N:8]3[N:7]=2)[CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54243131HCID 54243131, compound

Product 1

HCID 17924715HCID 17924715, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 2-(3-fluoro-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester (448 mg) in ethanol (10 ml) was added 2N sodium hydroxide and heated at reflux for 3 h. The cooled reaction mixture was acidified with 2N hydrochloric acid and the resulting solid isolated by filtration and dried in vacuo at 60° to give the title compound as an off-white solid (403 mg, 93%).

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 h
  3. customThe cooled reaction mixture
  4. customthe resulting solid isolated by filtration
  5. customdried in vacuo at 60°

Sources & evidence

ORD record
ord-e46deb3deaef444b979af1b00a47ce8e
Source dataset
uspto-grants-2007_05
Patent number
US07223772B1

Reaction notes

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