HCID 21104615, compound → HCID 21104620, compound

HRID 1354216Notes

Reaction equation

HRID 1354216 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=4)[N:16]=[CH:15][CH:14]=3)[CH2:7][CH2:6]2)[O:4]CC1>CC(O)=O.C1COCC1.O>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[C:13]2[CH2:12][CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 21104615HCID 21104615, compound

Product 1

HCID 21104620HCID 21104620, compound

Reagents, catalysts & solvents 1

HCID 21877175AcOH THF waterSolvent

Procedure

A solution of 4-[2-(1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl]-6-methoxy-quinoline (0.77 g, 2.35 mmol) in AcOH/THF/H2O (3/2/2, 10 ml) was stirred at 60° C. for 10 hours. The reaction mixture was concentrated to dryness by rotary evaporation. The residue was diluted with EtOAc (100 ml), washed with NaHCO3 (100 ml), dried over MgSO4, filtered and concentrated to dryness by rotary evaporation.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness by rotary evaporation
  2. additionThe residue was diluted with EtOAc (100 ml)
  3. washwashed with NaHCO3 (100 ml)
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-e782d741f9354049bb979dfad4a223f8
Source dataset
uspto-grants-2007_05
Patent number
US07223776B2

Reaction notes

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