HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine → 4-(6-Methoxyquinazolin-4-yloxymethyl)-cyclohexylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine | HCID 21104686 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(6-Methoxyquinazolin-4-yloxymethyl)-cyclohexylamine | HCID 21104633 | — |
Reaction Steps
20% Pd(OH)2 on carbon (1 g) was added to a solution of benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine (2 g, 5.3 mmol) in MeOH (30 ml) and hydrogenation was carried out under a hydrogen atmosphere (1 bar) at 65° C. The reaction mixture was filtered and the filtrate was concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223776B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-cfc85ad6d16b44d5b2ff6ba167a2863c |
| Source note | uspto-grants-2007_05 |