Benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine → HCID 21104633, compound

HRID 1354224Notes

Reaction equation

HRID 1354224 reaction equation
C([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][O:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[CH3:28][O:27][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[N:20]=[CH:19][N:18]=[C:17]2[O:16][CH2:15][CH:12]1[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]1

Participants

4

Reactant 1

HCID 21104686Benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine

Product 1

HCID 21104633HCID 21104633, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

20% Pd(OH)2 on carbon (1 g) was added to a solution of benzyl-[4-(6-methoxy-quinazolin-4-yloxymethyl)-cyclohexyl]-amine (2 g, 5.3 mmol) in MeOH (30 ml) and hydrogenation was carried out under a hydrogen atmosphere (1 bar) at 65° C. The reaction mixture was filtered and the filtrate was concentrated.

Workup

  1. customat 65° C
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cfc85ad6d16b44d5b2ff6ba167a2863c
Source dataset
uspto-grants-2007_05
Patent number
US07223776B2

Reaction notes

Loading…