HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178456287, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Reactant | 1-(Propan-2-yl)piperidin-4-amine dihydrochloride | HCID 17750340 | — |
| Reactant | HCID 178524958 | HCID 178524958 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178456287 | HCID 178456287 | — |
Reaction Steps
To 100 mg 5-Pyrrol-1-yl-1H-[1,2,4]triazole-3-carboxylic acid in 1 ml DMF and 0.3 ml NEt3, 121 mg 1-Isopropyl-piperidin-4-ylamine dihydrochloride and 142 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After addition of 5 ml of water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The obtained crude product was used without further purification in the next reaction step. Yield: 170 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223780B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-f8a53744db344ed1a5be955a6b6ffa6d |
| Source note | uspto-grants-2007_05 |