Water → HCID 178456287, compound

HRID 1354248Notes

Reaction equation

HRID 1354248 reaction equation
[N:1]1([C:6]2[NH:10][N:9]=[C:8]([C:11]([OH:13])=O)[N:7]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.Cl.Cl.[CH:16]([N:19]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]1)([CH3:18])[CH3:17].C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.O>CN(C=O)C.CCN(CC)CC>[CH:16]([N:19]1[CH2:24][CH2:23][CH:22]([NH:25][C:11]([C:8]2[N:7]=[C:6]([N:1]3[CH:2]=[CH:3][CH:4]=[CH:5]3)[NH:10][N:9]=2)=[O:13])[CH2:21][CH2:20]1)([CH3:18])[CH3:17]

Participants

7

Reactant 4

HCID 962WaterHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 177503401-(Propan-2-yl)piperidin-4-amine dihydrochlorideHCID 178524958HCID 178524958, compound

Product 1

HCID 178456287HCID 178456287, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

To 100 mg 5-Pyrrol-1-yl-1H-[1,2,4]triazole-3-carboxylic acid in 1 ml DMF and 0.3 ml NEt3, 121 mg 1-Isopropyl-piperidin-4-ylamine dihydrochloride and 142 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. After addition of 5 ml of water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The obtained crude product was used without further purification in the next reaction step. Yield: 170 mg.

Workup

  1. filtrationwas filtered through a chem elut® cartridge by elution with ethyl acetate
  2. concentrationconcentrated under reduced pressure
  3. customThe obtained crude product
  4. customwas used without further purification in the next reaction step

Sources & evidence

ORD record
ord-f8a53744db344ed1a5be955a6b6ffa6d
Source dataset
uspto-grants-2007_05
Patent number
US07223780B2

Reaction notes

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