HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1354294Generated: November 1, 2026
4-Aminopyridine → [2-(2-Fluoro-phenyl)-thieno[2,3-d]pyrimidin-4-yl]-pyridin-4-yl-amine
https://huagongshe.com/reaction/1354294
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 4-Chloro-2-(2-fluorophenyl)thieno[2,3-d]pyrimidine | HCID 21104336 | — |
| Catalyst | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | [2-(2-Fluoro-phenyl)-thieno[2,3-d]pyrimidin-4-yl]-pyridin-4-yl-amine | HCID 21104304 | 87.8% |
Reaction Steps
4-Chloro-2-(2-fluoro-phenyl)-thieno[2,3-d]pyrimidine (110 mg, 0.41 mmole) and 4-aminopyridine (78 mg, 0.830 mmole) were combined in isopropanol (3 ml), added 4 drops 4M HCl/dioxane and heated the reaction mixture to 80° C. for 7 hours. The reaction mixture was cooled and product isolated by filtration, washed with minimum cold methanol and dried under vacuum to give 116 mg product (yield: 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07223766B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-9da6b2c3a22f45268c4c8fd13653bebb |
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| Source note | uspto-grants-2007_05 |
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