反应详情

温度

80 °C

4-Chloro-2-(2-fluoro-phenyl)-thieno[2,3-d]pyrimidine (110 mg, 0.41 mmole) and 4-aminopyridine (78 mg, 0.830 mmole) were combined in isopropanol (3 ml), added 4 drops 4M HCl/dioxane and heated the reaction mixture to 80° C. for 7 hours. The reaction mixture was cooled and product isolated by filtration, washed with minimum cold methanol and dried under vacuum to give 116 mg product (yield: 86%).

1. temperatureThe reaction mixture was cooled
2. customproduct isolated by filtration
3. washwashed with minimum cold methanol
4. customdried under vacuum