Hydrogen Peroxide → 1-Amino-1H-pyrrole-2-carboxamide

HRID 1354304Notes

Reaction equation

HRID 1354304 reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]#[N:8].[OH-:9].[K+].OO>O>[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:8])=[O:9]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14797Potassium HydroxideHCID 99892301-Amino-1H-pyrrole-2-carbonitrile

Product 1

HCID 104191801-Amino-1H-pyrrole-2-carboxamideYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Amino-1H-pyrrole-2-carbonitrile (2.52 g, 23.5 mmole) was suspended in 75 ml water, treated with potassium hydroxide (32 g, 0.57 mole), 30% hydrogen peroxide (2 ml) and stirred overnight at room temperature. Cooled reaction mixture to 0° C. for 30 min and isolated product by filtration, washed with cold water and dried under vacuum to give 2.55 g product (yield: 87%)

Workup

  1. temperatureCooled
  2. customreaction mixture to 0° C. for 30 min
  3. customisolated product
  4. filtrationby filtration
  5. washwashed with cold water
  6. customdried under vacuum

Sources & evidence

ORD record
ord-c140a53b42da4d6088b4b1c4a03d58af
Source dataset
uspto-grants-2007_05
Patent number
US07223766B2

Reaction notes

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