HCID 58865961, compound → HCID 136007996, compound

HRID 1354305Notes

Reaction equation

HRID 1354305 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([CH:18]=1)[C:7]([NH:9][N:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]([NH2:17])=[O:16])=O>[OH-].[NH4+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:7]2[NH:17][C:15](=[O:16])[C:11]3=[CH:12][CH:13]=[CH:14][N:10]3[N:9]=2)[CH:18]=1

Participants

3

Reactant 1

HCID 58865961HCID 58865961, compound

Product 1

HCID 136007996HCID 136007996, compoundYield 48.1%

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

1-(5-Chloro-2-fluoro-benzoylamino)-1H-pyrrole-2-carboxylic acid amide (200 mg, 0.71 mmole) was dissolved in 5 ml 28% ammonium hydroxide in a sealed tube and heated to 80° C. overnight. Purged solution with nitrogen to remove excess ammonia and acidified with 1M hydrochloric acid to pH 2. Product was isolated by filtration, washed with water and vacuum dried to give 90 mg product (yield: 48%)

Workup

  1. customPurged solution with nitrogen to remove excess ammonia
  2. customProduct was isolated by filtration
  3. washwashed with water and vacuum
  4. customdried

Sources & evidence

ORD record
ord-ac9d0a8758484e1a8cb10fbeb55adcfe
Source dataset
uspto-grants-2007_05
Patent number
US07223766B2

Reaction notes

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