反应详情

The product from step (a) (1.75 g) and 4-chloro-2,5-difluorobenzonitrile (1.86 g) in dry DMF (40 ml) were treated with 60% sodium hydride in mineral oil (470 mg) with stirring under nitrogen. The reaction mixture was stirred for 2.5 h, poured into water, and extracted with ethyl acetate. The extract was washed with water (5×) then brine and dried (MgSO4). The solvent was evaporated and the residue purified by chromatography (silica, 10% ether/isohexane as eluent) to give the sub-title compound (2.37 g) as a pale yellow oil.

1. stirringThe reaction mixture was stirred for 2.5 h
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water (5×)
4. dry with materialbrine and dried (MgSO4)
5. customThe solvent was evaporated
6. customthe residue purified by chromatography (silica, 10% ether/isohexane as eluent)