Triphenylphosphine → HCID 86598976, compound

Participants

Role	Name	HCID	Charge
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	2,5-Dichlorobenzenethiol	HCID 79965	—
Reactant	Diethyl azodicarboxylate	HCID 5462977	—
Reactant	tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate	HCID 9816137	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 86598976	HCID 86598976	25%

Reaction Conditions

Temperature	0 °C

Reaction Steps

To a solution of triphenylphosphine (1.97 g), 2,5-dichlorothiophenol (0.90 g) and the product from step (a) (1.48 g) in THF (30 ml) under nitrogen at 0° C. was added diethylazodicarboxylate (1.18 ml) dropwise and the mixture was stirred at 0° C. for 45 minutes, then at room temperature for 72 h. The mixture was concentrated and the residue purified by chromatography (silica, 10% ethyl acetate/isohexane as eluent) to give the sub-title compound as a clear oil (500 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07223794B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-3c9accd6e1924450b2289bc1a57ce99c
Source note	uspto-grants-2007_05