反应详情

温度

0 °C

To a solution of triphenylphosphine (1.97 g), 2,5-dichlorothiophenol (0.90 g) and the product from step (a) (1.48 g) in THF (30 ml) under nitrogen at 0° C. was added diethylazodicarboxylate (1.18 ml) dropwise and the mixture was stirred at 0° C. for 45 minutes, then at room temperature for 72 h. The mixture was concentrated and the residue purified by chromatography (silica, 10% ethyl acetate/isohexane as eluent) to give the sub-title compound as a clear oil (500 mg).

1. waitat room temperature for 72 h
2. concentrationThe mixture was concentrated
3. customthe residue purified by chromatography (silica, 10% ethyl acetate/isohexane as eluent)