Oxalic Acid → HCID 178510127, compound

HRID 1354398Notes

Reaction equation

HRID 1354398 reaction equation
Cl.[OH:2][CH2:3][C:4](=[NH:8])OCC.[C:9]([OH:14])(=[O:13])[C:10]([OH:12])=[O:11].C(O)(=O)/C=C/C(O)=O.[NH2:23][CH2:24][C@@H:25]([O:32][C:33]1[CH:40]=[C:39]([Cl:41])[C:38]([F:42])=[CH:37][C:34]=1[C:35]#[N:36])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:9]([OH:14])(=[O:13])[C:10]([OH:12])=[O:11].[Cl:41][C:39]1[C:38]([F:42])=[CH:37][C:34]([C:35]#[N:36])=[C:33]([CH:40]=1)[O:32][CH:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:24][NH:23][C:4](=[NH:8])[CH2:3][OH:2].[Cl:41][C:39]1[C:38]([F:42])=[CH:37][C:34]([C:35]#[N:36])=[C:33]([CH:40]=1)[O:32][CH:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:24][NH:23][C:4](=[NH:8])[CH2:3][OH:2]

Participants

4

Reactant 3

HCID 971Oxalic AcidHCID 12383662Ethyl 2-hydroxyacetimidate hydrochlorideHCID 1317264602-[[(1S)-2-Amino-1-phenylethyl]oxy]-4-chloro-5-fluorobenzonitrile (E)-butenedioate

Product 1

HCID 178510127HCID 178510127, compound

Procedure

The title compound was prepared by the method of Example 5 using ethyl 2-hydroxyethanimidate hydrochloride in metianol and the ethanedioic acid salt of the product from Example 1 step (c). M.p. 196° C.

Sources & evidence

ORD record
ord-48239bd7ecd147b8a7a5d020c6e134f9
Source dataset
uspto-grants-2007_05
Patent number
US07223794B2

Reaction notes

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