Sodium borohydride → HCID 19351381, compound

HRID 1354403Notes

Reaction equation

HRID 1354403 reaction equation
[O:1]=[C:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[BH4-].[Na+]>C(O)C>[OH:1][CH:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 58993194tert-Butyl [2-oxo-2-(pyridin-3-yl)ethyl]carbamate

Product 1

HCID 19351381HCID 19351381, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the product from step (b) (1.30 g) in ethanol (50 ml) was added sodium borohydride (105 mg). The mixture was stirred for 1.5 h then evaporated. Water was added and the mixture extracted twice with ethyl acetate. The combined organic layers were washed (brine) and dried (MgSO4). The solvent was evaporated off to give the sub-title compound (1.35 g) as an oil.

Workup

  1. customthen evaporated
  2. additionWater was added
  3. extractionthe mixture extracted twice with ethyl acetate
  4. washThe combined organic layers were washed (brine)
  5. dry with materialdried (MgSO4)
  6. customThe solvent was evaporated off

Sources & evidence

ORD record
ord-822bfe8892a74c148d6c5ff5b093b398
Source dataset
uspto-grants-2007_05
Patent number
US07223794B2

Reaction notes

Loading…