Sodium borohydride → Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate

Participants

Reaction Steps

To a solution of the product from step (b) (1.30 g) in ethanol (50 ml) was added sodium borohydride (105 mg). The mixture was stirred for 1.5 h then evaporated. Water was added and the mixture extracted twice with ethyl acetate. The combined organic layers were washed (brine) and dried (MgSO4). The solvent was evaporated off to give the sub-title compound (1.35 g) as an oil.

Provenance & Evidence