HCID 21106103, compound → HCID 178435259, compound

HRID 1354577Notes

Reaction equation

HRID 1354577 reaction equation
C([N:8]1[C:12]([C:13]2([CH2:23][CH3:24])[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([F:22])[CH:19]=3)[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Ni]>[CH2:23]([C:13]1([C:12]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([F:22])[CH:19]=2)[CH2:14]1)[CH3:24]

Participants

4

Reactant 1

HCID 21106103HCID 21106103, compound

Product 1

HCID 178435259HCID 178435259, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

10 ml of the crude product obtained in Example 3 was placed in a round-bottomed flask equipped with a thermometer and a stirring bar. 1.5 ml of Raney-Nickel in ethanol (Raney-Nickel prepared according to Vogel, Practical Organic Chemistry, 5th Edition, 1999, Longman, U.K. p. 450–451), was added under nitrogen atmosphere. The reaction mixture was stirred at reflux temperature for about 14 hours. After filtration and evaporation crude 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole was obtained.

Workup

  1. customequipped with a thermometer and a stirring bar
  2. temperatureat reflux temperature for about 14 hours
  3. filtrationAfter filtration
  4. customevaporation crude 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole
  5. customwas obtained

Sources & evidence

ORD record
ord-41c11414a84646d8a0c0fb827fa0c92b
Source dataset
uspto-grants-2007_05
Patent number
US07223871B2

Reaction notes

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