HCID 21106103, compound → HCID 178435259, compound

Participants

Reaction Steps

10 ml of the crude product obtained in Example 3 was placed in a round-bottomed flask equipped with a thermometer and a stirring bar. 1.5 ml of Raney-Nickel in ethanol (Raney-Nickel prepared according to Vogel, Practical Organic Chemistry, 5th Edition, 1999, Longman, U.K. p. 450–451), was added under nitrogen atmosphere. The reaction mixture was stirred at reflux temperature for about 14 hours. After filtration and evaporation crude 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole was obtained.

Provenance & Evidence