HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamic chloride → HCID 22021251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamic chloride | HCID 68048 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Piperidinamine | HCID 424361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22021251 | HCID 22021251 | — |
Reaction Steps
A solution of the 4-amino-piperidine compound (˜50–100 mmol) in 5 ml MeOH is cooled to 0° C. Then ˜10 equivalent of Huenigs base and ˜3 equivalent of carbamoyl chloride are added. The vial is shaken once and allowed to stand at ambient temperature overnight. Evaporation of volatiles and purification by prep. HPLC gives the 4-carbamoyl-aminopiperidine compounds.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223757B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-b1f391bcb9bd4cb89b14f6c5a77e670c |
| Source note | uspto-grants-2007_05 |