Carbamic chloride → HCID 22021251, compound

HRID 1354652Notes

Reaction equation

HRID 1354652 reaction equation
N[CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CC[N:10](C(C)C)C(C)C.[C:17](Cl)(=[O:19])[NH2:18]>CO>[C:17]([CH:2]1[CH2:7][CH2:6][N:5]([NH2:10])[CH2:4][CH2:3]1)(=[O:19])[NH2:18]

Participants

5

Reactant 3

HCID 68048Carbamic chlorideHCID 81531DiisopropylethylamineHCID 4243614-Piperidinamine

Product 1

HCID 22021251HCID 22021251, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the 4-amino-piperidine compound (˜50–100 mmol) in 5 ml MeOH is cooled to 0° C. Then ˜10 equivalent of Huenigs base and ˜3 equivalent of carbamoyl chloride are added. The vial is shaken once and allowed to stand at ambient temperature overnight. Evaporation of volatiles and purification by prep. HPLC gives the 4-carbamoyl-aminopiperidine compounds.

Workup

  1. customEvaporation of volatiles and purification by prep

Sources & evidence

ORD record
ord-b1f391bcb9bd4cb89b14f6c5a77e670c
Source dataset
uspto-grants-2007_05
Patent number
US07223757B2

Reaction notes

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