HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Aminophenoxy)benzene → 1-[4-(4-Dimethylaminopiperidin-1-yl)phenyl]-3-(4-phenoxyphenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Aminophenoxy)benzene | HCID 8764 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N,N-Dimethylpiperidin-4-amine | HCID 417391 | — |
| Reactant | 1-(4-aminophenyl)-N,N-dimethylpiperidin-4-amine | HCID 10889414 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | 1-[4-(4-Dimethylaminopiperidin-1-yl)phenyl]-3-(4-phenoxyphenyl)urea | HCID 10320492 | — |
Reaction Steps
Dimethylpiperidin-4-ylamine was reacted with 4-fluoronitrobenzene, the resulting nitro compound was reduced with hydrogen and finally the aniline ([1-(4-aminophenyl)piperidin-4-yl]dimethylamine) was reacted with CDI and 4-phenoxyaniline by method A, B and C. This resulted in the product with the molecular weight of 430.55 (C26H30N4O2); MS (ESI): 431 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223788B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-ea27a03d8e4a4069a5739c371e59cd10 |
| Source note | uspto-grants-2007_05 |