Aniline → HCID 10004660, compound

HRID 1354678Notes

Reaction equation

HRID 1354678 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.F[C:14]1[CH:19]=CC([N+]([O-])=O)=[CH:16][CH:15]=1.[H][H].NC1C=CC=CC=1.[CH:32]1N=C[N:34]([C:37]([N:39]2C=N[CH:41]=[CH:40]2)=[O:38])[CH:33]=1.[CH:44]1([O:49][C:50]2[CH:56]=[CH:55]C(N)=C[CH:51]=2)[CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH:44]1([O:49][C:50]2[CH:51]=[CH:41][C:40]([NH:39][C:37]([NH:34][C:33]3[CH:32]=[CH:16][C:15]([N:1]4[CH2:6][CH2:5][CH:4]([N:7]5[CH2:12][CH2:11][O:10][CH2:9][CH2:8]5)[CH2:3][CH2:2]4)=[CH:14][CH:19]=3)=[O:38])=[CH:55][CH:56]=2)[CH2:45][CH2:46][CH2:47][CH2:48]1

Participants

7

Reactant 6

HCID 6115AnilineHCID 9590p-FluoronitrobenzeneHCID 682631,1'-CarbonyldiimidazoleHCID 7957244-MorpholinopiperidineHCID 64844484-(cyclopentyloxy)anilineHCID 178418361HCID 178418361, compound

Product 1

HCID 10004660HCID 10004660, compound

Procedure

4-Piperidin-4-ylmorpholine was reacted with 4-fluoronitrobenzene, the resulting nitro compound was reduced with hydrogen and finally the aniline was reacted with CDI and 4-cyclopentyloxyaniline by method A, B and C. This resulted in the product with the molecular weight of 464.61 (C27H36N4O3); MS (ESI): 465 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 464.61 (C27H36N4O3)

Sources & evidence

ORD record
ord-bcf64cd922c5495a8e98de75844cc74a
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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