1,1'-Carbonyldiimidazole → N-(1-{4-[3-(6-Cyclopentyloxypyridin-3-yl)ureido]phenyl}pyrrolidin-3-yl)-N-methylacetamide

HRID 1354688Notes

Reaction equation

HRID 1354688 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:17])[C:14](=[O:16])[CH3:15])[CH2:9]2)=[CH:4][CH:3]=1.[C:18](N1C=CN=C1)(N1C=CN=C1)=[O:19].[CH:30]1([O:35][C:36]2[N:41]=[CH:40][C:39]([NH2:42])=[CH:38][CH:37]=2)[CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH:30]1([O:35][C:36]2[N:41]=[CH:40][C:39]([NH:42][C:18](=[O:19])[NH:1][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:12][CH2:11][CH:10]([N:13]([CH3:17])[C:14](=[O:16])[CH3:15])[CH2:9]4)=[CH:6][CH:7]=3)=[CH:38][CH:37]=2)[CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 167909726-(Cyclopentyloxy)pyridin-3-amineHCID 21105566N-[1-(4-aminophenyl)pyrrolidin-3-yl]-N-methylacetamide

Product 1

HCID 10094621N-(1-{4-[3-(6-Cyclopentyloxypyridin-3-yl)ureido]phenyl}pyrrolidin-3-yl)-N-methylacetamide

Procedure

N-[1-(4-aminophenyl)pyrrolidin-3-yl]-N-methylacetamide was reacted with carbonyldiimidazole and then 6-cyclopentyloxypyridin-3-ylamine by method A. This resulted in the product with the molecular weight of 437.55 (C24H31N5O3); MS (ESI): 438 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 437.55 (C24H31N5O3)

Sources & evidence

ORD record
ord-da2717a3ffb4464fb2c52160096a5837
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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