Bromomethylcyclopropane → HCID 21105535, compound

HRID 1354735Notes

Reaction equation

HRID 1354735 reaction equation
Br[CH2:2][CH:3]1[CH2:5][CH2:4]1.[CH3:6][N:7]([CH3:29])[CH:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[N:23][CH:22]=3)=[CH:15][CH:14]=2)[CH2:9]1>>[CH:5]1([CH2:4][O:27][C:24]2[CH:25]=[CH:26][C:21]([C:20]([NH:19][C:16]3[CH:15]=[CH:14][C:13]([N:10]4[CH2:11][CH2:12][CH:8]([N:7]([CH3:29])[CH3:6])[CH2:9]4)=[CH:18][CH:17]=3)=[O:28])=[CH:22][N:23]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 178482923HCID 178482923, compound

Product 1

HCID 21105535HCID 21105535, compound

Procedure

(Bromomethyl)cyclopropane was reacted with N-[4-(3-dimethylaminopyrrolidin-1-yl)-phenyl]-6-hydroxynicotinamide by method H-a. This resulted in the product with the molecular weight of 380.22 (C22H28N4O2); MS (ESI): 381 (M+H+) as hydrotrifluoroacetate.

Workup

  1. customThis resulted in the product with the molecular weight of 380.22 (C22H28N4O2)

Sources & evidence

ORD record
ord-e6ae558b3e4042108bcda738a18dba6c
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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