4-Methylpiperidine → HCID 21105503, compound

HRID 1354782Notes

Reaction equation

HRID 1354782 reaction equation
FC(F)(F)S(O[C:7]1[CH:8]=[CH:9][C:10]([C:13]([O:15]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:14])=[N:11][CH:12]=1)(=O)=O.[CH3:31][CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH3:31][CH:32]1[CH2:37][CH2:36][N:35]([C:7]2[CH:12]=[N:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 693814-MethylpiperidineHCID 10873809HCID 10873809, compound

Product 1

HCID 21105503HCID 21105503, compound

Procedure

Benzhydryl 5-trifluoromethanesulfonyloxypyridine-2-carboxylate (3.0 g) was heated with 4-methylpiperidine (1.4 g) at 80° C. for one hour. The reaction mixture was immediately purified by preparative HPLC and then hydrogenated in analogy to method. This resulted in the product with the molecular weight of 220.27 (C12H16N2O2); MS (ESI): 221 (M+H+).

Workup

  1. customThe reaction mixture was immediately purified by preparative HPLC
  2. customThis resulted in the product with the molecular weight of 220.27 (C12H16N2O2)

Sources & evidence

ORD record
ord-2f936c3668e34c888c5d965a3da5d296
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

Loading…