反应详情

Methyl 4-(1-hydroxyethyl)benzoate (2.0 g) dissolved in DMF (30 ml) was mixed with propyl iodide (3.8 g), and then sodium hydride (50% in oil, 0.53 g) was added. After the end of the exothermic reaction, the mixture was stirred for 1 hour and then water was cautiously added. It was extracted with ethyl acetate, and the organic phase was dried over sodium sulfate, filtered and concentrated. The residue was hydrolyzed by method P-a. This resulted in the product with the molecular weight of 208.26 (C12H16O3); MS (ESI): 209 (M+H+).

1. customAfter the end of the exothermic reaction
2. extractionIt was extracted with ethyl acetate
3. dry with materialthe organic phase was dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThis resulted in the product with the molecular weight of 208.26 (C12H16O3)