HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1354809Generated: October 31, 2026
Phosphorus oxychloride → 2-Chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile
https://huagongshe.com/reaction/1354809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(4-Methylphenyl)-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile | HCID 21103210 | — |
| Product | 2-Chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile | HCID 21103198 | — |
Reaction Steps
A mixture of 6-(4-methylphenyl)-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile (11-3) (5.73 g, 20.01 mmol) in POCl3 (50 mL) was heated to 100° C. overnight. Cooled and concentrated in vacuo. The residue was basified with sat. aqueous Na2CO3 solution and then extracted with CH2Cl2. The combined organic layers was dried, filtered and concentrated to give 2-chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile (11-4) as a solid. LRMS m/z (M+H) Calcd: 305.1, found: 305.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07223738B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-602b2216ebbd413e8177686fcea9732a |
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| Source note | uspto-grants-2007_05 |
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