反应详情

温度

100 °C

A mixture of 6-(4-methylphenyl)-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile (11-3) (5.73 g, 20.01 mmol) in POCl3 (50 mL) was heated to 100° C. overnight. Cooled and concentrated in vacuo. The residue was basified with sat. aqueous Na2CO3 solution and then extracted with CH2Cl2. The combined organic layers was dried, filtered and concentrated to give 2-chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile (11-4) as a solid. LRMS m/z (M+H) Calcd: 305.1, found: 305.2.

1. temperatureCooled
2. concentrationconcentrated in vacuo
3. extractionextracted with CH2Cl2
4. customThe combined organic layers was dried
5. filtrationfiltered
6. concentrationconcentrated