HCID 18506763, compound → HCID 12042412, compound

HRID 1355348Notes

Reaction equation

HRID 1355348 reaction equation
C([NH:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[CH3:22])[C:15](=[O:25])[C:14]([C:26]([O:28]CC)=[O:27])=[CH:13]2)[C:9]([F:31])=[CH:8][C:7]=1[F:32])(C)(C)C>Cl>[NH2:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[CH3:22])[C:15](=[O:25])[C:14]([C:26]([OH:28])=[O:27])=[CH:13]2)[C:9]([F:31])=[CH:8][C:7]=1[F:32]

Participants

3

Reactant 1

HCID 18506763HCID 18506763, compound

Product 1

HCID 12042412HCID 12042412, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 2.5 g of ethyl 1-(6-t-butylamino-3,5-difluoropyridin-2-yl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was added 10 mL of 36% hydrochloric acid, followed by heating under reflux overnight. After the reaction mixture was allowed to cool down, the resulting precipitate was collected by filtration. The precipitate was washed with ethanol and then with diethyl ether, whereby 1.7 g of the title compound was obtained as a pale yellow powder.

Workup

  1. temperatureby heating
  2. temperatureunder reflux overnight
  3. temperatureto cool down
  4. filtrationthe resulting precipitate was collected by filtration
  5. washThe precipitate was washed with ethanol

Sources & evidence

ORD record
ord-4b0e4824972641489befeb103243170b
Source dataset
uspto-grants-2003_07
Patent number
US06586420B1

Reaction notes

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