Hydrazine hydrate (1:1) → HCID 9835424, compound

HRID 1355357Notes

Reaction equation

HRID 1355357 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1.O.[NH2:23][NH2:24]>O1CCOCC1>[NH:23]([C:3]1[N:4]=[N:5][C:6]([C:20]#[N:21])=[C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[N:8]=1)[NH2:24]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18506776HCID 18506776, compound

Product 1

HCID 9835424HCID 9835424, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure as described in example 4 the 3-methylsulfanyl-5-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-[1,2,4] triazine-6-carbonitrile was reacted with hydrazine hydrate in dioxane at 140° C. during 3 hours to give 3-hydrazino-5-(1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-[1,2,4]triazine-6-carbonitrile as a yellow amorphous powder; MS: 282 (M+H)+.

Sources & evidence

ORD record
ord-c65eb907626b4c58b3ea75168a48c9ce
Source dataset
uspto-grants-2003_07
Patent number
US06586422B2

Reaction notes

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