4-(Chloromethyl)-5-methyl-1-trityl-1H-imidazole → 4-[7-Methyl-3,3-bis-(5-methyl-1-trityl-1h-imidazol-4-ylmethyl)-1-naphthalen-1-ylmethyl-2-oxo-2,3-dihydro-1h-indol-6-yl]-benzonitrile
Reaction equation
[CH3:1][C:2]1[C:3]([C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=2)=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:8](=[O:22])[CH2:7]2.Cl[CH2:32][C:33]1[N:34]=[CH:35][N:36]([C:39]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:37]=1[CH3:38]>>[CH3:1][C:2]1[C:3]([C:23]2[CH:24]=[CH:25][C:26]([C:27]#[N:28])=[CH:29][CH:30]=2)=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:8](=[O:22])[C:7]2([CH2:32][C:33]1[N:34]=[CH:35][N:36]([C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)([C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)[C:37]=1[CH3:38])[CH2:32][C:33]1[N:34]=[CH:35][N:36]([C:39]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:37]=1[CH3:38]Participants
3
Reactant 2
Product 1
Procedure
Following the same procedure as described in example 14A, the reaction of the title compound of 13A (0.191 g, 0.49 mmol) and 4-chloromethyl-5-methyl-1-trityl-1H-imidazole (0.55 g, 1.48 mmol) yielded the title compound of 15A (282.2 mg, 71% yield).
Sources & evidence
- ORD record
- ord-a385154589e3404e87c6305d6cfa2625
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06586447B1
Reaction notes
Loading…