Pyridine → HCID 18507567, compound

HRID 1355700Notes

Reaction equation

HRID 1355700 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.S(Cl)(Cl)=O.[NH2:16][C:17]1[N:22]=[C:21]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=2)[C:20]([C:35]#[N:36])=[CH:19][N:18]=1.N1C=CC=CC=1>ClCCl>[C:35]([C:20]1[C:21]([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=2)=[N:22][C:17]([NH:16][C:9](=[O:11])[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[I:1])=[N:18][CH:19]=1)#[N:36]

Participants

6

Reactant 4

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 27800902-Iodophenylacetic acidHCID 18507677HCID 18507677, compound

Product 1

HCID 18507567HCID 18507567, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

From 2-iodophenylacetic acid, thionyl chloride and N,N-in dichloromethane. Then treatment with 2-amino-5-cyano-4-(3,4,5-trimethoxyphenyl)pyrimidine and pyridine in dichloromethane. ES-MS m/e (%): 553 (M+Na+, 15), 531 (M+H+, 100).

Sources & evidence

ORD record
ord-89e5041e619a4241967d318fd0ff14dd
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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