N,N-Dimethylethylenediamine → 2-Amino-4-(2-dimethylamino-ethylamino)-6-furan-2-yl-pyrimidine-5-carbonitrile

HRID 1355752Notes

Reaction equation

HRID 1355752 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)(=O)=O)[N:3]=1.[CH3:19][N:20]([CH3:24])[CH2:21][CH2:22][NH2:23]>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([NH:23][CH2:22][CH2:21][N:20]([CH3:24])[CH3:19])[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

4

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 185073992-Amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile

Product 1

HCID 185074902-Amino-4-(2-dimethylamino-ethylamino)-6-furan-2-yl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile and 2-dimethylaminoethylamine in DME. ES-MS m/e (%): 273 (M+H+, 100), 228 ([M—Me2NH]+, 80).

Sources & evidence

ORD record
ord-9b0f4305c3d44b8ebb594116c30ece33
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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