N-Piperidinoethanol → HCID 18507657, compound

HRID 1355754Notes

Reaction equation

HRID 1355754 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)(=O)=O)[N:3]=1.[OH:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[N:3]=1

Participants

5

Reactant 3

HCID 18232N-PiperidinoethanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185073992-Amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile

Product 1

HCID 18507657HCID 18507657, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile, hydroxyethylpiperidine and DBU in DME. ES-MS m/e (%:314 (M+H+, 100).

Sources & evidence

ORD record
ord-5136ff076b954de7936f597f00679372
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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