Phenethyl bromide → 2-Amino-4-phenethylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

HRID 1355766Notes

Reaction equation

HRID 1355766 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[S:16])[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[CH2:17](Br)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.CC[O-].[Na+]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1

Participants

5

Reactant 3

HCID 7666Phenethyl bromideHCID 2723922Sodium ethoxideHCID 178509378HCID 178509378, compound

Product 1

HCID 185075182-Amino-4-phenethylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

From 2-amino-4-phenyl-6-thioxo-1,6-dihydro-pyrimidine-5-carbonitrile, phenethyl bromide and sodium ethylate in ethanol. ES-MS m/e (%): 333 (M+H+, 100).

Sources & evidence

ORD record
ord-6dfaec9a73644d0e95def622f8e590c6
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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