Cyclohexanol → HCID 18507332, compound

HRID 1355780Notes

Reaction equation

HRID 1355780 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.[CH:17]1([OH:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:23][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1

Participants

5

Reactant 3

HCID 7966CyclohexanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507370HCID 18507370, compound

Product 1

HCID 18507332HCID 18507332, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-chloro-6-phenyl-pyrimidine-5-carbonitrile, cyclohexanol and DBU in DME. EI-MS m/e (%): 294 (M+, 12), 213 ([M—C6H9]+, 100), 212 ([M—C6H10]+, 48), 170 (60).

Sources & evidence

ORD record
ord-75d02f75c43c4e5fac4d7d889e1fa4c3
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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