HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylfuran → 5-Bromo-4-(2-furyl)-2-pyrimidinylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylfuran | HCID 14505 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-4-(2-furyl)-2-pyrimidinylamine | HCID 18507263 | — |
Reaction Steps
From 2-acetylfuran and N,N-dimethylformamide dimethyl acetal in DMF. Then treatment with guanidine carbonate and sodium methylate in methanol. Then treatment with N-bromosuccinimide in acetic acid. EI-MS m/e (%): 241 (M{81Br}+, 98), 239 (M{81Br}+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-68d521d2a63a4b7e87ca2322655afbeb |
| Source note | uspto-grants-2003_07 |