Acrylonitrile → HCID 18507315, compound

HRID 1355838Notes

Reaction equation

HRID 1355838 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11](I)=[C:10]([S:13][CH3:14])[N:9]=[C:8]([NH2:15])[N:7]=1.[C:16](#[N:19])[CH:17]=[CH2:18].C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH2:15][C:8]1[N:7]=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[C:11](/[CH:18]=[CH:17]/[C:16]#[N:19])=[C:10]([S:13][CH3:14])[N:9]=1

Participants

6

Reactant 3

HCID 7855AcrylonitrileHCID 10796Cesium carbonateHCID 185075894-Furan-2-yl-5-iodo-6-methylsulfanyl-pyrimidin-2-ylamine

Product 1

HCID 18507315HCID 18507315, compound

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

From 4-furan-2-yl-5-iodo-6-methylsulfanyl-pyrimidin-2-ylamine, acrylonitrile, bis(triphenylphosphine)palladium(II) chloride and cesium carbonate in dioxane. EI-MS m/e (%): 258 (M+, 76), 241 ([M—NH3]+, 100), 150 (56), 114 (32).

Sources & evidence

ORD record
ord-58547058a24641a9ab3493e7834c2489
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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