O-Methyltyramine → 5-Bromo-6-furan-2-yl-N4-[2-(4-methoxy-phenyl)-ethyl]-pyrimidine-2,4-diamine

HRID 1355854Notes

Reaction equation

HRID 1355854 reaction equation
[Br:1][C:2]1[C:3]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[N:4][C:5]([NH2:11])=[N:6][C:7]=1S(C)=O.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH2:27])=[CH:21][CH:20]=1>O1CCOCC1>[Br:1][C:2]1[C:7]([NH:27][CH2:26][CH2:25][C:22]2[CH:23]=[CH:24][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)=[N:6][C:5]([NH2:11])=[N:4][C:3]=1[C:12]1[O:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 4657O-MethyltyramineHCID 185072865-Bromo-4-furan-2-yl-6-methanesulfinyl-pyrimidin-2-ylamine

Product 1

HCID 185076285-Bromo-6-furan-2-yl-N4-[2-(4-methoxy-phenyl)-ethyl]-pyrimidine-2,4-diamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 5-bromo-4-furan-2-yl-6-methanesulfinyl-pyrimidin-2-yl-amine and 2-(4-methoxyphenyl)ethylamine in dioxane. ES-MS m/e (%): 391 (M{81Br}+H+, 100), 389 (M{79Br}+H+, 99).

Sources & evidence

ORD record
ord-4d8722f26a9a4e86bd39f4b4ddc07968
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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