4-Hydroxymethylpyridine → HCID 18507349, compound

HRID 1355894Notes

Reaction equation

HRID 1355894 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.[OH:18][CH2:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[N:3]=1

Participants

5

Reactant 3

HCID 114724-HydroxymethylpyridineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

Product 1

HCID 18507349HCID 18507349, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, 4-(hydroxymethyl)pyridine and DBU in DME. EI-MS m/e (%): 293 (M+, 100), 92 (40), 65 (39).

Sources & evidence

ORD record
ord-70937a2fa8b54cd8a6d1525793e5f322
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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