Cyclohexanol → 5-Bromo-4-furan-2-yl-6-phenoxy-pyrimidin-2-yl-amine

HRID 1355900Notes

Reaction equation

HRID 1355900 reaction equation
[Br:1][C:2]1[C:3]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[N:4][C:5]([NH2:11])=[N:6][C:7]=1S(C)=O.[CH:17]1([OH:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C1CCN2C(=NCCC2)CC1>O1CCOCC1>[Br:1][C:2]1[C:3]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[N:4][C:5]([NH2:11])=[N:6][C:7]=1[O:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 7966CyclohexanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185072865-Bromo-4-furan-2-yl-6-methanesulfinyl-pyrimidin-2-ylamine

Product 1

HCID 185075745-Bromo-4-furan-2-yl-6-phenoxy-pyrimidin-2-yl-amine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 5-bromo-4-furan-2-yl-6-methanesulfinyl-pyrimidin-2-yl-amine, cyclohexanol and DBU in dioxane. EI-MS m/e (%): 339 (M{81Br}+, 15), 337 (M{79Br}+, 16), 257 ([M—C6H10]+, 97), 255 ([M—C6H]+, 100).

Sources & evidence

ORD record
ord-a957671dd4c246469cb03e0b49f6ad0e
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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