Cyclohexanol → 2-Amino-4-cyclohexyloxy-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

HRID 1355942Notes

Reaction equation

HRID 1355942 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[C:5]([C:14]#[N:15])=[C:4](SC)[N:3]=1.[CH:18]1([OH:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([O:24][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:5]([C:14]#[N:15])=[C:6]([C:8]2[O:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[N:7]=1

Participants

5

Reactant 3

HCID 7966CyclohexanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185073082-Amino-4-(5-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

Product 1

HCID 185076332-Amino-4-cyclohexyloxy-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-(5-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile, cyclohexanol and DBU in DME. ES-MS m/e (%): 299 (M+H+, 50), 217 (M+H—C6H10+, 100).

Sources & evidence

ORD record
ord-61d39a5508d54da8bff45342545b2db3
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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