1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(4-dimethylamino-benzylamino)-6-furan-2-yl-pyrimidine-5-carbonitrile

HRID 1355982Notes

Reaction equation

HRID 1355982 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.Cl.Cl.[CH3:20][N:21]([CH3:30])[C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([NH:27][CH2:26][C:25]2[CH:28]=[CH:29][C:22]([N:21]([CH3:30])[CH3:20])=[CH:23][CH:24]=2)[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 27346334-(aminomethyl)-N,N-dimethylaniline dihydrochlorideHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

Product 1

HCID 102685742-Amino-4-(4-dimethylamino-benzylamino)-6-furan-2-yl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, 4-dimethylaminobenzylamine dihydrochloride and DBU in DME. ES-MS m/e (%): 335 (M+H+, 100).

Sources & evidence

ORD record
ord-b73312fef37a48d0bcc63ad7178c5da9
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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