(5-Methylpyridin-2-yl)methanamine → 6-Amino-2-furan-2-yl-4-[(5-methyl-pyridin-2-yl-methyl)-amino]-nicotinonitrile

HRID 1356045Notes

Reaction equation

HRID 1356045 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](OS(C(F)(F)F)(=O)=O)[CH:3]=1.[CH3:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:30][NH2:31])=[N:28][CH:29]=1>COCCOC>[NH2:1][C:2]1[CH:3]=[C:4]([NH:31][CH2:30][C:27]2[CH:26]=[CH:25][C:24]([CH3:23])=[CH:29][N:28]=2)[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

4

Reactant 2

HCID 11423586(5-Methylpyridin-2-yl)methanamineHCID 86583754Trifluoromethanesulfonic acid 6-amino-3-cyano-2-furan-2-yl-pyridin-4-yl ester

Product 1

HCID 99662596-Amino-2-furan-2-yl-4-[(5-methyl-pyridin-2-yl-methyl)-amino]-nicotinonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From trifluoromethanesulfonic acid 6-amino-3-cyano-2-furan-2-yl-pyridin-4-yl ester and C-(5-methyl-pyridin-2-yl)-methylamine in DME. ES-MS m/e (%): 328 (M+Na+, 30), 306 (M+H+, 100).

Sources & evidence

ORD record
ord-b6bdec865e574b8ca19a7e47fb20c7e5
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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