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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1356045Generated: October 25, 2026

(5-Methylpyridin-2-yl)methanamine → 6-Amino-2-furan-2-yl-4-[(5-methyl-pyridin-2-yl-methyl)-amino]-nicotinonitrile

https://huagongshe.com/reaction/1356045

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Methylpyridin-2-yl)methanamineHCID 11423586—
ReactantTrifluoromethanesulfonic acid 6-amino-3-cyano-2-furan-2-yl-pyridin-4-yl esterHCID 86583754—
Solvent1,2-DimethoxyethaneHCID 8071—
Product6-Amino-2-furan-2-yl-4-[(5-methyl-pyridin-2-yl-methyl)-amino]-nicotinonitrileHCID 9966259—

Reaction Steps

From trifluoromethanesulfonic acid 6-amino-3-cyano-2-furan-2-yl-pyridin-4-yl ester and C-(5-methyl-pyridin-2-yl)-methylamine in DME. ES-MS m/e (%): 328 (M+Na+, 30), 306 (M+H+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06586441B2
Source datasetuspto-grants-2003_07
ORD IDord-b6bdec865e574b8ca19a7e47fb20c7e5
Source noteuspto-grants-2003_07