1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 18507358, compound

HRID 1356064Notes

Reaction equation

HRID 1356064 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[C:5]([C:15]#[N:16])=[C:4](S(C)=O)[N:3]=1.N1C=CC=CC=1C([OH:28])C.[CH2:29]1[CH2:39][CH2:38][N:37]2C(=N[CH2:34][CH2:35][CH2:36]2)C[CH2:30]1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[C:5]([C:15]#[N:16])=[C:4]([O:28][CH2:34][CH2:35][C:36]2[CH:30]=[CH:29][CH:39]=[CH:38][N:37]=2)[N:3]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 86784alpha-Methyl-2-pyridinemethanolHCID 18507562HCID 18507562, compound

Product 1

HCID 18507358HCID 18507358, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-(2-fluoro-phenyl)-6-methanesulfinyl-pyrimidine-5-carbonitrile, (2-pyridyl)ethanol and DBU in DME. ES-MS m/e (%): 336 (M+H+, 100).

Sources & evidence

ORD record
ord-2d184adc363b427fbb8a5edf1a507cfc
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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