1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 18507540, compound

HRID 1356111Notes

Reaction equation

HRID 1356111 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1.[ClH:18].NCC1C(Cl)=CC=C([C:28]([F:31])([F:30])[F:29])N=1.[CH2:32]1[CH2:42][CH2:41][N:40]2[C:35](=[N:36]CCC2)[CH2:34][CH2:33]1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([NH:36][CH2:35][C:34]2[C:33]([Cl:18])=[CH:32][C:42]([C:28]([F:31])([F:30])[F:29])=[CH:41][N:40]=2)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507481HCID 18507481, compoundHCID 185075202-Amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

Product 1

HCID 18507540HCID 18507540, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, 2-aminomethyl-3-chloro-6-(trifluoromethyl)pyridine hydrochloride and DBU in DME. ES-MS m/e (%): 397 (M{37Cl}+H+, 25), 395 (M{35Cl}+H+, 100).

Sources & evidence

ORD record
ord-72154b08651e4c1dad4063c4440a6ece
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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