Benzyl Alcohol → 2-Amino-4-benzyloxy-6-(pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

HRID 1356156Notes

Reaction equation

HRID 1356156 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:3]=1.[CH2:19]([OH:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:26][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:5]([C:9]#[N:10])=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:3]=1

Participants

5

Reactant 3

HCID 244Benzyl AlcoholHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185074852-Amino-4-chloro-6-(pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

Product 1

HCID 185074442-Amino-4-benzyloxy-6-(pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-chloro-6-(pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile, benzyl alcohol and DBU in DME. ES-MS m/e (%): 356 (MNa+, 50), 334 (M+H+, 100).

Sources & evidence

ORD record
ord-641c6f1945d642a4ae081496dce8c87c
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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